The Uzi is a related family of open bolt, blowback-operated submachine guns. Smaller variants are considered to be machine pistols. The Uzi was one of the first weapons to use a telescoping bolt design which allows for the magazine to be housed in the pistol grip for a shorter weapon. The first Uzi submachine gun was designed by Major Uziel Gal in the late 1940s. The prototype was finished in 1950; first introduced to IDF special forces in 1954, the weapon was placed into general issue two years later. The Uzi has found use as a personal defense weapon by rear-echelon troops, officers, artillery troops and tankers, as well as a frontline weapon by elite light infantry assault forces. The Uzi has been exported to over 90 countries. Over its service lifetime, it has been manufactured by Israel Military Industries, FN Herstal, and other manufacturers. From the 1960s through the 1980s, Uzi submachine guns were sold to more military and police markets than any other submachine gun ever made.

The Uzi is used in The Getaway: Black Monday and is considered Eddie's best overall weapon, replacing all other weapons when one is held. With its fast rate of fire, great accuracy and damage, the Uzi truly holds up to its status, and it can also accept a silencer, other than being dual-wieldable. It becomes available first in the mission The Rescue and appears in most other missions afterwards.